Antimutagenic components in Spatholobus suberectus Dunn against N-methyl-N-nitrosourea
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چکیده
منابع مشابه
In Vitro Study on Anti-Hepatitis C Virus Activity of Spatholobus suberectus Dunn.
Hepatitis C virus (HCV) infects 200 million people worldwide, and 75% of HCV cases progress into chronic infections, which consequently cause cirrhosis and hepatocellular carcinoma. HCV infection is treated with currently considered standard drugs, including direct anti-viral agents (DAAs), alone or in combination with peginterferon-α plus ribavirin. However, sustained viral responses vary in d...
متن کاملEffect of total flavonoids of Spatholobus suberectus Dunn on PCV2 induced oxidative stress in RAW264.7 cells
BACKGROUND This study was carried out to investigate the effect of total flavonoids of Spatholobus suberectus Dunn (TFSD) on PCV2 induced oxidative stress in RAW264.7 cells. METHODS Oxidative stress model was established in RAW264.7 cells by infecting with PCV2. Virus infected cells were then treated with various concentrations (25 mg/ml, 50 mg/ml and 100 mg/ml) of TFSD. The levels of oxidati...
متن کاملProtective effects of pregnancy and lactation against N-methyl-N-nitrosourea-induced mammary carcinomas in female Lewis rats.
The role of parity before and after N-methyl-N-nitrosourea (MNU) treatment in protection against mammary carcinogenesis was investigated. The effect of lactation on reduction in the incidence of mammary carcinoma was also examined. Parous rats were compared with respective age-matched virgins (AMVs). Pregnancy and lactation prior to MNU exposure significantly reduced both the incidence of mamma...
متن کاملEffects of short-term pregnancy hormone treatment against N-methyl-N-nitrosourea-induced mammary carcinomas in female Lewis rats.
AIM To study the effects of short-term pregnancy hormone treatment, estradiol and progesterone or prolactin, against pre-existing mammary cancer as well as newly developing mammary cancer by using the N-methyl-N-nitrosourea (MNU)-induced rat mammary cancer model. MATERIALS AND METHODS Three-week-old female Lewis rats (n=103) received an intraperitoneal injection of 50 mg/kg MNU. Nine weeks af...
متن کاملDNA base changes and alkylation following in vivo exposure of Escherichia coli to N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea.
Dideoxy chain-termination DNA sequencing was used to determine the specific DNA base changes induced after in vivo exposure of Escherichia coli to N-methyl-N-nitrosourea (MNU) and N-ethyl-N-nitrosourea (ENU) using the xanthine guanine phosphoribosyltransferase (gpt) gene as the genetic target. The resultant mutation spectra were compared with the levels of O6-alkylguanine and O4-alkylthymidine ...
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ژورنال
عنوان ژورنال: Genes and Environment
سال: 2019
ISSN: 1880-7062
DOI: 10.1186/s41021-019-0137-4